A modest Midwesterner who became one of the most influential geneticists of the first half of the 20th century, William E. Castle spent his career at Harvard and the University of California working on patterns of inheritance in mice, horses, and a variety of other mammalian taxa. An early proponent of Mendelian theory, Castle was director of the Bussey Institution at Harvard for almost thirty years, helping to train a number of important geneticists. The Castle Papers contain one linear foot of correspondence dating primarily from the period after Castle's "retirement" to Berkeley in 1936 until his death in 1962, dealing almost exclusively with his research on horse breeding and the inheritance of coat coloration in horses. Castle's correspondence with his former student L. C. Dunn is an exception, focusing on mouse genetics and ranging to a variety of topics from the conduct of scientific research during the Second World War to Castle's interests in the early history of genetics.

Sewall Wright ranks among the most influential figures in the field of population genetics during the 20th century, and made important contributions to biostatistics, biometrics, and evolutionary theory. These papers contain much of Wright's professional correspondence, scattered research notes, and drafts of a small number of papers.